Harriet Thorpe will reprise her role as Madame Morrible in Wicked from April 22 to November 16.
She replaces Louise Plowright, who has withdrawn from the role due to ill health.
A spokesperson for the show said the company wishes her a full and speedy recovery.
Thorpe previously appeared in the role from April 2008 until March 2010.
Wicked, which is based on the novel by Gregory Maguire, is currently running at London’s Apollo Victoria Theatre.