Gerard McCarthy and Oliver Wilson will join the previously announced Robert Bathurst in the cast of Blue/Orange.
The play, written by Joe Penhall, was originally performed in 2000 at the National’s Cottesloe theatre.
Directed by Christopher Luscombe, this is the second show from Theatre Royal Brighton Production’s inaugural season, which was launched in 2011.
Howard Panter, Adam Speers and Evanna White from Ambassador Theatre Group will produce the play.
Blue/Orange will run at the Theatre Royal Brighton from September 13 to 22 before touring the UK and then transferring to the West End.